Sedation with non sedating antihistamines

"The first-generation antihistamines are more sedating, but the distinction isn't as black-and-white as the marketing of the newer products may lead you to believe.The difference between them is really blurred." "Under some circumstances, the nonsedating formulas do cause sedation and in some cases, these sedating formulas do not," he tells Web MD.

" April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.

Some second-generation antihistamines, notably cetirizine, can interact with CNS psychoactive drugs such as bupropion and benzodiazepines.-antihistamines are among first-line therapy to treat gastrointestinal conditions including peptic ulcers and gastroesophageal reflux disease. Most side effects are due to cross-reactivity with unintended receptors.

Cimetidine, for example, is notorious for antagonizing androgenic testosterone and DHT receptors at high doses.

Antihistamines that target the histamine H receptors in the upper gastrointestinal tract, primarily in the stomach.

Histamine receptors exhibit constitutive activity, so antihistamines can function as either a neutral receptor antagonist or an inverse agonist at histamine receptor.

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" These newer products, which include Allegra, Zyrtec, and Claritin, generally cost between 10 to 20 times as much as the older, "first-generation" products.

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